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Anti-phospholipid Syndrome OverviewAnti-phospholipid syndrome is the most common acquired risk factor for both venous and arterial thrombosis. Thrombotic events are reported in approximately 30% of patients with elevated levels of anti-phospholipid antibodies with overall occurrence of 2.5% of patients/year. Problems with using Anti-cardiolipin (ACA) as the only anti-phospholipid antibody used to screen for anti-phospholipid syndrome –Some antibodies detected by anti-cardiolipin (ACA) are not associated with APS. ‘Infectious’ antiphospholipid Abs (false positive ACA) are not associated with thrombosis. Solutions containing bovine serum as a source of β2GP1 have been used as blocking agents or as sample diluents in most ELISA tests for ACA antibodies. Some of the antibodies detected may be directed to bovine proteins not associated with APS and thus produce false positive results for ACA. Many patients with antiphospholipid syndrome have only borderline positive ACA antibodies. Why test for β2GP1 IgG in addition to other anti-phospholipid antibodies?Positive results in at least 2 assays may enhance the diagnosis of APS (58% of APS patients have 3 APS Abs) as patients with autoimmune diseases including SLE and infections rarely have more than 2 antibodies (0-15% of SLE / autoimmune patients have 3 positive APS Abs)
Why use one of our β2GP1 IgG kits?The College of American Pathologists (CAP) Survey – in both the 1998 & 1999 survey there was one specimen which consistently gave positive results by Corgenix IgG and IgA β2 Glycoprotein 1 kits but was negative by all other methods. The patient had a diagnosis of antiphospholipid syndrome with multiple thrombotic episodes and had a positive lupus anti-coagulant. A study conducted at Royal Brisbane Hospital (RBH) showed that on patients with high ACA results all kits gave positive β2GP1 results. However overall correlation, especially at low ACA values, was far superior for the Corgenix kit. The 7th International Symposium on Anti-phospholipid Antibodies suggested that this linear relationship between ACA and β2GP1 should be expected, thus supporting the RBH study. Reference Mr Bob Wilson, Autoimmune Dept., Royal Brisbane Hospital Ph: (07) 3253
8047 Product Details Product Description Part # Corgenix β2GP1 IgG* 96 well kit CG037-001 Genesis β2GP1 IgG* 96 test kit GD31 For pricing and additional information, please phone your local Abacus Diagnostics sales representative or contact us at Info@AbacusDx.com * Kits are also available for β2GP1 IgA and β2GP1 IgM
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