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Diagnostics
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Hypertension and Pheochromocytoma – An Overview
Although it accounts for less than 1% of cases, pheochromocytoma is important to distinguish from other causes of hypertension. Unrecognised, the disease can be fatal. Pheochromocytoma is a catecholamine-secreting tumour that arises from adrenal medullary or sympathetic ganglion tissue.
Pheochromocytoma produces an excess of adrenalin, noradrenalin, dopamine and their methoxy derivatives metanephrine, and normetanephrine. Diagnosis is usually made by the detection of abnormally high levels of one or more of these substances in urine or plasma. Despite a variety of disadvantages, for the last twenty years measurement has been mainly by High-Performance Liquid Chromatography (HPLC). This technology is usually restricted to use in large laboratories due to the prohibitive cost of installation, maintenance and training—not to mention the ongoing technical challenges.
The new CatCombi ELISA kit from manufacturer IBL Hamburg provides for the quantitative measurement of Adrenalin and Noradrenalin in both plasma and urine. It offers significant advantages over other methods.
Significant Advantages
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unique 1 day assay (total assay time of 6 hours) |
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increased sensitivity and increased specificity compared to HPLC |
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only 10µl of urine or 300µl of plasma per sample is required |
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excellent correlation of ELISA v GCMS and HPLC (r= 0.98) |
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easy handling and robust assay characteristics |
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not susceptible to interferences from therapeutic drugs including anti–hypertensives |
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low technical requirements |
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non-radioactive method |
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Simple & simultaneous extraction of adrenalin and noradrenalin in both plasma and urine |
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urine and plasma samples can be assayed in parallel using only one common standard curve |
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broad standard range: 0-150 ng/mL Adrenalin and 0-500 ng/mL Noradrenalin |
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separate ELISA kits for adrenalin, noradrenalin, metanephrine and normetanephrine also available |
Product Description Part #
CatCombi ELISA 2 x 96 wells IBRE59242
Adrenalin ELISA 1 x 96 wells IBRE59251
Noradrenalin ELISA 1 x 96 wells IBRE59261