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Discover the latest guidelines
The process for identifying patients with monoclonal gammopathies can be complex. Initial detection of a monoclonal immunoglobulin protein (M protein) in the serum or urine often requires compilation of analytical data from several areas of the laboratory.
Different algorithms exist worldwide for such testing. The College of American Pathology (CAP) has published new guidelines recently to strengthen the early detection of an M protein inpatients displaying symptoms or with monoclonal gammopathy and harmonize inter-lab variability.
Immunotyping, an alternative method to serum Immunofixation
Out of the nine guideline statements, the College of American Pathologists strongly recommend: “Laboratorians should confirm an SPEP abnormality suspicious for presence of an M protein with additional testing by sIFE or alternative method with similar sensitivity”.
Serum immunofixation (sIFE) is routinely used in clinical laboratories to confirm the presence of an M-protein and determine its isotype. Immunotyping (IT) by Capillary Electrophoresis is an alternative method to IF with similar sensitivity and becomes widely used particularly for laboratories looking for automated solution.
