Interrogate COVID-19 with Tecan’s Neopterine ELISA
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Applying Tecan products to research
Neopterin indicates a plethora of infections before the onset of symptoms. Today I want to highlight a paper investigating the relationship of neopterin and Covid-19.
Neopterin levels were measured with the Tecan: Neopterin ELISA (RE59321).
Key message:
Innate immune activation during Covid-19 infection is associated with pernicious clinical outcome.
Background:
- Coronavirus disease 2019 (Covid-19) became a pandemic.
- Pre-existing comorbidities play a detrimental role in the course of Covid-19.
- Previous coronavirus epidemics, notably SARS-CoV, were associated with increased serum neopterin levels.
- Neopterin serves as a sign of acute innate immunity in response to viral infection. Authors propose neopterin may serve as: A biomarker of SARS-CoV-2 viral infection and an indicator of Covid-19 disease severity.
Neopterin levels and survival of patients
The authors investigated the course of patients from the time symptoms occurred to discharge or death. The survival curves for Covid-19 patients (above) indicate that elevated neopterin levels (>53nm) correlated with a lower probability of survival, while lower levels (<53nM) in serum concentration led to a higher chance of survival.
- Severe and critically ill SARS-CoV-2 infected patients had elevated neopterin blood levels.
- Neopterin levels >19nM stratified healthy individuals from Covid-19 patients
- Neopterin levels >53nM differentiated non-survivors from survivors
Reference:
- Chauvin, M., Larsen, M., Quirant, B., Quentric, P., Dorgham, K., Royer, L., … & Sauce, D. (2021). Elevated neopterin levels predict fatal outcome in SARS-CoV-2-infected patients. Frontiers in cellular and infection microbiology, 764
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