Interrogate COVID-19 with Tecan’s Neopterine ELISA

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Applying Tecan products to research

Neopterin indicates a plethora of infections before the onset of symptoms. Today I want to highlight a paper investigating the relationship of neopterin and Covid-19.

Neopterin levels were measured with the Tecan: Neopterin ELISA (RE59321).
 

Key message:

Innate immune activation during Covid-19 infection is associated with pernicious clinical outcome.
 
Background:

• Coronavirus disease 2019 (Covid-19) became a pandemic.
• Pre-existing comorbidities play a detrimental role in the course of Covid-19.
• Previous coronavirus epidemics, notably SARS-CoV, were associated with increased serum neopterin levels.
• Neopterin serves as a sign of acute innate immunity in response to viral infection. Authors propose neopterin may serve as: A biomarker of SARS-CoV-2 viral infection and an indicator of Covid-19 disease severity.

Neopterin levels and survival of patients

The authors investigated the course of patients from the time symptoms occurred to discharge or death. The survival curves for Covid-19 patients (above) indicate that elevated neopterin levels (>53nm) correlated with a lower probability of survival, while lower levels (<53nM) in serum concentration led to a higher chance of survival.

Reference:

1. Chauvin, M., Larsen, M., Quirant, B., Quentric, P., Dorgham, K., Royer, L., … & Sauce, D. (2021). Elevated neopterin levels predict fatal outcome in SARS-CoV-2-infected patients. Frontiers in cellular and infection microbiology, 764

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