New Publication: A Novel Approach to Estimating M-Protein Concentration: Capillary Electrophoresis Quantitative Immunosubtraction

Last updated: 28th August, 2018

Abacus dx and Sebia are pleased to advise you of a new publication:

Title: A Novel Approach to Estimating M-Protein Concentration: Capillary Electrophoresis Quantitative Immunosubtraction

Authors:  Lee F. Schroeder, Forest Huls, Christopher L. Williams, Shih-Hon Li, and David F. Keren

Article Summary:
Current multiple myeloma guidelines consider M-proteins under 1 g/dL to be unmeasurable and, due to masking by non-immunoglobulin proteins, recommend nephelometric IgA measurements for IgA M-proteins migrating in the β-region.

This inability to accurately quantify low-concentration M-protein presents a barrier to early identification of relapse and subsequent treatment adjustment. In this manuscript, the authors show proof of principle for a method of quantitative immunosubtraction, which improves M-protein measurement by reducing the masking effects of both polyclonal immunoglobulin and non-immunoglobulin proteins.

This pilot shows the method can reduce the limit of M-protein quantification below 0.1 g/dL in the difficult-to-measure β-region.

 

Due to copyright we are unable to share the full article.  Please click here to view the abstract.

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