New Publication: A Novel Approach to Estimating M-Protein Concentration: Capillary Electrophoresis Quantitative Immunosubtraction
Abacus dx and Sebia are pleased to advise you of a new publication:
Title: A Novel Approach to Estimating M-Protein Concentration: Capillary Electrophoresis Quantitative Immunosubtraction
Authors: Lee F. Schroeder, Forest Huls, Christopher L. Williams, Shih-Hon Li, and David F. Keren
Current multiple myeloma guidelines consider M-proteins under 1 g/dL to be unmeasurable and, due to masking by non-immunoglobulin proteins, recommend nephelometric IgA measurements for IgA M-proteins migrating in the β-region.
This inability to accurately quantify low-concentration M-protein presents a barrier to early identification of relapse and subsequent treatment adjustment. In this manuscript, the authors show proof of principle for a method of quantitative immunosubtraction, which improves M-protein measurement by reducing the masking effects of both polyclonal immunoglobulin and non-immunoglobulin proteins.
This pilot shows the method can reduce the limit of M-protein quantification below 0.1 g/dL in the difficult-to-measure β-region.
Due to copyright we are unable to share the full article. Please click here to view the abstract.