Cell Marque Somatostatin Receptor 2A (EP149) Rabbit Monoclonal Primary Antibody

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Somatostatin Receptor 2A (SSTR2A) is a protein highly expressed in pancreas binding somatostatin and inhibiting pancreatic enzyme secretion.¹ 

SSTR2A is used as a marker for identifying meningioma from other spindle-cell tumors such as solitary fibrous tumor.^2,3 SSTR2A is more frequently expressed in higher grade meningiomas and associated to its microvessel proliferation.⁴ SSTR2A has demonstrated utility as a diagnostic marker for follicular dendritic cell sarcomas and some other related tumors.⁵

References

1. Kailey, Balrik et al. “SSTR2 is the functionally dominant somatostatin receptor in human pancreatic β- and a-cells.” American journal of physiology. Endocrinology and metabolism vol. 303,9 (2012): E1107-16. doi:10.1152/ajpendo.00207.2012
2. Menke, Joshua R et al. “Somatostatin receptor 2a is a more sensitive diagnostic marker of meningioma than epithelial membrane antigen.” Acta neuropathologica vol. 130,3 (2015): 441-3. doi:10.1007/s00401-015-1459-3
3. Boulagnon-Rombi, Camille et al. “Immunohistochemical Approach to the Differential Diagnosis of Meningiomas and Their Mimics.” Journal of neuropathology and experimental neurology vol. 76,4 (2017): 289-298. doi:10.1093/jnen/nlx008
4. Barresi, V et al. “Sstr2A immunohistochemical expression in human meningiomas: is there a correlation with the histological grade, proliferation or microvessel density?.” Oncology reports vol. 20,3 (2008): 485-92.
5. Tao, Li-Li et al. “SSTR2a Is a Useful Diagnostic Marker for Follicular Dendritic Cells and Their Related Tumors.” The American journal of surgical pathology vol. 43,3 (2019): 374-381. doi:10.1097/PAS.0000000000001205

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