Importance of LC3 in Autophagy
LC3 plays an integral role as an autophagosome maker, because it resides in the entire process of autophagosome formation. Upon autophagy induction, LC3-I, a small and soluble cytoplasmic protein, is conjugated with a phospholipid which anchors it to the autophagosomal membrane as LC3-II. Autophagy can be induced by nutrient deprivation.
MBL’s polyclonal and monoclonal antibodies can be used to quantify LC3-I and LC3-II levels within the cell.
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