HEp-2 versus HEp-2000® – What is the difference?

What is the difference? The HEp-2000® ANA Test System uses transfected mitotic human epithelioid cells (HEp-2). Historically, HEp-2 cells with mitotic figures have shown greater sensitivity and sharper pattern recognition than rodent kidney substrates. HEp-2000® contains HEp-2 cells transfected with multiple copies of the specific DNA sequence for the SSA/Ro autoantigen. Approximately 10-20% of the […]

Immuno Concepts – Technical Bulletin 2025 Q2

Immuno Concepts are leaders in the development of state-of-the-art diagnostic assays for systemic rheumatic diseases. Immuno Concepts not only pioneered the conversion from rodent tissue to HEp-2 cells for the detection of anti-nuclear antibodies (ANAs) but also overcame one of the main pitfalls of ANA detection with the introduction of HEp-2000®, a patented ANA substrate […]

Immuno Concepts – Technical Bulletin 2024 Q4

Immuno Concepts are leaders in the development of state-of-the-art diagnostic assays for systemic rheumatic diseases. Immuno Concepts not only pioneered the conversion from rodent tissue to HEp-2 cells for the detection of anti-nuclear antibodies (ANAs) but also overcame one of the main pitfalls of ANA detection with the introduction of HEp-2000®, a patented ANA substrate […]