Spotlight on NKX3.1

NKX3.1 is a prostate-specific homeobox gene protein whose expression is predominantly localized to prostate epithelium. It acts as a transcription factor involved in prostate development. Anti-NKX3.1 labels prostate epithelium, both malignant and benign, with a nuclear visualization. Studies have shown that NKX3.1 immunostaining compares favorably to PSA immunostaining in sensitivity of metastatic prostate adenocarcinoma.1 NKX3.1 is recommended to be included in a diagnostic panel with PSA, PSAP, cytokeratin 34betaE12, and GATA3.2

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Prostate Cancer

Novel Nuclear Transcription Factors for Prostate:

Over 220,000 men are diagnosed in the United States each year with prostate cancer, and over 27,000 deaths occur annually as a result.1 Early detection and definitive diagnosis is important! Scientific advancements in cancer detection have developed rapidly to keep up with the prevalence of this disease. Recent detection advancements include the development of antibodies NKX3.1 and ERG. These transcription factors aid in the immunohistochemical diagnosis of prostate cancer.

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Importance of LC3 in Autophagy

LC3 plays an integral role as an autophagosome maker, because it resides in the entire process of autophagosome formation. Upon autophagy induction, LC3-I, a small and soluble cytoplasmic protein, is conjugated with a phospholipid which anchors it to the autophagosomal membrane as LC3-II. Autophagy can be induced by nutrient deprivation.

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