Alpha thalassemia is a genetic blood disorder that affects haemoglobin production, leading to varying degrees of anaemia. With global migration increasing the prevalence of thalassemia worldwide, early and accurate screening is more important than ever.
The i+LAB αTHAL IC Strip Test from i+MED Laboratories is a rapid, visually read lateral flow immunoassay designed to detect Hb Bart’s, a key biomarker found in individuals with alpha thalassemia syndromes. This includes carriers of alpha thalassemia 1, Hb H disease, Hb Bart’s hydrops fetalis, and homozygous alpha thalassemia 2.
How It Works
The test uses a monoclonal antibody that binds specifically to Hb Bart’s in hemolysed whole blood. A coloured band appears on the test strip to indicate a positive result, while a control line confirms the test has functioned correctly. Results are available within minutes, with no need for specialised equipment.
Clinical Performance
Validated across multiple centers, the i+LAB αTHAL IC Strip Test demonstrates:
- 100% sensitivity and 73.1% specificity for alpha thalassemia 1
- 97.4% sensitivity and 93% specificity for alpha thalassemia 1 and homozygous alpha thalassemia 2
These performance metrics make it a reliable tool for population screening, especially in regions with high prevalence or limited access to molecular diagnostics.
Key Benefits
- Fast and easy-to-use: Results in 2–5 minutes
- No instrumentation required
- Detects a wide range of alpha thalassemia syndromes
- Supports genetic counselling and prevention strategies
Safety and Handling
The test and its associated controls are derived from human source material and should be handled as potentially infectious. Standard biosafety precautions apply. The kit is stable at 4°C to 30°C and includes all necessary reagents for 50 tests.
THESE PRODUCTS ARE NOT AVAILABLE FOR PURCHASE BY THE GENERAL PUBLIC.
