New Levels of Allergy Management: Olive Components
An allergy diagnosis is based on the history, clinical symptoms and physical examination of the patient in combination with results of sIgE tests.
ImmunoCAP® Molecular Allergology takes the diagnosis and management of allergy to a whole new level. The technology uses single allergen components to quantitatively detect IgE antibodies. A single blood sample enables measurement to all available ImmunoCAP components, providing precise results for better risk assessment. ImmunoCAP Allergen Components help differentiate “true” allergies from symptoms due to cross-reactivity, evaluate the risk of severe reactions and help in defining the optimal specific immunotherapy treatment. Benefits that ultimately can improve the patient’s quality of life.
Sensitization to olive pollen normally varies between 5–40 % in olive pollen areas.
The presence of at least 20 proteins with allergic activity has been demonstrated in Olive pollen. However, more than 70 % of patients with sensitization to olive pollen have IgE antibodies to Ole e 1.
The frequency of sensitization to Ole e 7 and Ole e 9 varies strongly between different areas (0–50 %). Sensitization to the cross-reactive allergens profilin, polcalcin and CCD is usually less frequent (< 20 %).
In addition to being a major olive pollen allergen, Ole e 1 is also a marker for sensitization to ash pollens, as well as privet,and lilac pollens since they are closely botanically related.
Ole e 7 is a non-specific lipid transfer protein (nsLTP) with limited homology and cross-reactivity to other nsLTPs. Sensitisation to Ole e 7 has been associated with a propensity to adverse reactions.
Ole e 9, has been shown to be a major allergen of olive pollen, and may play a role in pollen-latex-fruit syndrome.
Olive pollens can induce asthma, allergic rhinitis and allergic conjunctivitis in sensitised individuals. A well-founded olive pollen diagnosis and proper immunotherapy can reduce allergic symptoms and improve the quality of life of the patients.
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