Clinical Utility of ImmunoCAP Tryptase

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ImmunoCAP Tryptase is a well-known clinical marker in explaining severe reactions cause by insect venoms, drugs, or in systemic mastocytosis. High-baseline tryptase levels can indicate if a person may be predisposed to severe anaphylactic reactions; and precautionary measures, e.g., an epinephrine autoinjector and specific immunotherapy, may be considered.

Tryptase and Venoms

• Tryptase can support the clinical assessment regarding need for therapy in patients being considered for venom-specific immunotherapy after previous reactions to bee and/or wasp stings
• Tryptase can help guide VIT treatment and in deciding on lifelong treatment

Typtase and Drug Reactions

• Tryptase levels can assist in finding the cause of a severe reaction which can occur during surgery
• Measurements of transiently elevated tryptase levels directly after the reaction can help to identify if the reaction was due to mast cell activation

Typtase and Mastocystosis

• Tryptase baseline levels reflect the mast cell burden in the body
• Together with clinical findings, ImmunoCAP Tryptase test results can help to rule in or rule out systemic mastocystosis
• WHO (World Health Organization) minor diagnostic criterion for systemic mastocytosis includes a persistently elevated baseline serum tryptase value above 20 μg/l (1 μg/l = 1 ng/ml)

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