Thermo Fisher – Pernicious Anemia Testing

Identify pernicious anemia patients with high accuracy

EliA Intrinsic Factor and EliA Parietal Cell – safe and efficient antibody testing to aid in the diagnosis of pernicious anemia.

Two autoantibodies help to explain the cause of anemia
Pernicious anemia (PA) is the late stage of autoimmune atrophic gastritis¹ and accounts for 20%-50% of the causes of vitamin B12 deficiency in adults². The vitamin B12 deficiency is the result of two factors:

• A lack of intrinsic factor, caused by the destruction of parietal cells in the stomach that produce this glycoprotein.¹
• The blockage of intrinsic factor, caused by intrinsic factor antibodies preventing the absorption of the intrinsic factor-Vitamin B12-complex in the ileum.¹

The predominant patient symptoms relate more to anemic status than to gastric disorders. The prevalence of PA is 0.1 % in the general population and reaches 1.9 % in patients over 60.²

A definitive diagnosis of PA is important because affected patients need lifelong treatment with vitamin B12.^3,4

Simplify pernicious anemia diagnostics on an intuitive,
automated, tailor-made platform.

References:

1. Toh BH and Alderuccio F; Autoimmunity 37 2004: 357–361
2. Andres E, Serraj K; Optimal management of pernicious anemia. Journal of Blood Medicine 2012: 3 97–103
3. Devalia V et al.; Guidelines for the diagnosis and treatment of cobalamin and folate disorders. Br J Haematol. 166 2014: 496–513
4. Varbanova M et al.; Chronic gastritis – an update. Best Pract Res Clin Gastroenterol. 28 2014: 1031–42

THESE PRODUCTS ARE NOT AVAILABLE FOR PURCHASE BY THE GENERAL PUBLIC.