IDS Urinary CTX-II biomarker for knee osteoarthritis

Last updated: 26th April, 2023

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Early diagnosis of knee osteoarthritis (OA) remains a diagnostic challenge.

Urinary C-terminal crosslinked telopeptide of type II collagen (urinary CTX-II) is one of the potential OA biomarkers.

Arunrukthavon et al1., study published at Arthroplasty in 2020 concluded that

  • Patients with knee OA had higher urinary CTX-II levels than healthy controls (Figure).
  • Levels of urinary CTX-II were independently correlated with radiographic severity of knee OA.
  • Age, gender, and patient-reported outcomes exerted no effect on the urinary CTX-II levels.

Comparison of the levels of urinary CTX-II between knee OA patients and controls:

Find out more about our IVD product: Urine CartiLaps (CTX-ll) EIA

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  1. Piti Arunrukthavon, Danai Heebthamai, Prapasri Benchasiriluck, Supinda Chaluay, Thanainit Chotanaphuti, Saradej Khuangsirikul. Can urinary CTX-II be a biomarker for knee osteoarthritis?  Arthroplasty. 2020; 2(1):6. doi: 10.1186/s42836-020-0024-2.

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