Products are for professional/laboratory use only.
ELISA for the quantitative determination of Calprotectin in stool samples. Increased Calprotectin values are an indicator for:
- Acute and chronic inflammatory bowel disease (IBD)
- Differentiation between active inflammatory bowel disease and irritable bowel syndrome (IBS)
- Monitoring of Crohn´s disease and ulcerative colitis or polyp excavation
Calprotectin (S100A8/S100A9-Heterotetramer) is a calcium- and zinc-binding polypeptide from neutrophil granulocytes (PMN), it is located in the intestinal mucosa and has an antibacterial function (Dale et al., 1985; Däbritz et al., 2014). Calprotectin is a sensitive and very specific parameter for the detection of intestinal inflammation since detection of Calprotectin in stool correlates with the migration of granulocytes from the intestinal wall into the intestinal lumen (Guerrant, Araujo et al., 1992). Calprotectin can be used for monitoring as well as for distinguishing between inflammatory bowel diseases (IBD), such as Crohn’s disease and ulcerative colitis, and non-inflammatory irritable bowel syndrome (IBS) (Kane, Sandborn et al., 2003, Kapral, Duller et al., 2004, Sipponen, Savilahti et al., 2008).
Main advantages:
- High stability allows time for convenient mailing of samples
- No weighing of the stool samples
- No centrifuge of the samples
- Incubation at room temperature and without shaking of the ELISA plate
- Monoclonal antibodies
