Invivoscribe launches MRD T-Cell Bundled Solution

Last updated: 05th March, 2020

Abacus dx is pleased to announce the launch of the Invivoscribe MRD T-Cell Bundled Solution* which includes LymphoTrack T-Cell Low Positive Controls, LymphoQuant T-Cell Internal Controls and NGS-powered LymphoTrack Dx Assays. The new Research Use Only (RUO) controls are optimised for T-cell receptor gene rearrangement testing and analysis with Invivoscribe’s complimentary LymphoTrack MRD Software.

Key Benefits of the LymphoTrack MRD Bundled Solution

  • Use LymphoTrack Dx Assays for clonality assessment and for MRD tracking
  • LymphoTrack Low Positive Control provides confidence in results.
  • LymphoQuant Internal Control enables conversion of sequencing reads into clonotype cell equivalents for accurate tracking over time without any additional sequencing cost.
  • LymphoTrack MRD Software sorts complex multiplexed NGS data for simplified analysis and visualisation of longitudinal samples.
  • Objectively identify and monitor sequence specific mutation status of TR gene rearrangements using the same LymphoTrack Dx Assays. 
  • The LymphoTrack MRD T-cell controls are validated for use with the MiSeq® (TRG and TRB Assays) and Ion S5™/Ion PGM™ (TRG Assay) systems.

MRD Bundled Solution for Monitoring

The MRD Bundle contains the necessary external and internal controls, master mixes and software to identify and assess mutation status of T-cell gene rearrangements in haematologic samples.  Invivoscribe has demonstrated mean sensitivity of 10-4 across TRG and 10-3 across TRB during performance testing of Low Positive Controls.  Furthermore, the LymphoTrack Dx Assays demonstrated excellent linearity (R2 > 0.99) and agreement with the expected values when contrived samples were spiked with LymphoQuant T-cell Internal Control and tested from 10-2 to 10-5.

View the MRD Technical Bulletin

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Find out more about the Bundled Solution for MRD

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*Each product available for separate purchase only and when used altogether forms a solution for MRD testing.  Please check regulatory requirements in your country.


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