New ZytoVision ZytoLight® SPEC GATA2/MECOM Dual Colour Fusion Probe
Abacus dx is pleased to announce the release of the latest probe from ZytoVision, ZytoLight® SPEC GATA2/MECOM Dual Color Fusion Probe.
The ZytoLight ® SPEC GATA2/MECOM Dual Color Dual Fusion Probe is designed to detect the inversion inv(3)(q21q26.2) and the translocation t(3;3)(q21;q26.2) both affecting the GATA2 (a.k.a. NFE1B) gene in the chromosomal region 3q21.3 and the MECOM (MDS1 and EVI1 complex locus, a.k.a. MDS1, EVI1) gene in 3q26.2.
In the revised 2016 WHO classification of Myeloid Neoplasms and Acute Leukemia (Arber et al., 2016) a own NEW entity is classified as “AML with inv(3)(q21.3q26.2) or t(3;3) (q21.3;q26.2); GATA2, MECOM” emphasizing the unique clinic pathologic features and poorer prognosis of this subgroup of AML patients. Chromosome 3q26.2 rearrangements may be cryptic on standard karyotype analysis. Hence, FISH may be a helpful tool to confirm the diagnosis of this distinct AML subgroup.
The ZytoLight® SPEC GATA2/MECOM Dual Color Dual Fusion Probe is available as 5 tests.