A uniquely designed ALK/EML4 TriCheck FISH probe for lung cancer diagnosis

Last updated: 01st September, 2017
Zytovision’s ZytoLight products allow for reliable, highly sensitive and specific detection of genetic aberrations (e.g. translocations, deletions, amplifications and chromosomal aneuploidies) by using fluorescence in situ hybridization (FISH) in formalin-fixed, paraffin-embedded tissue sections, cell samples, blood or bone marrow smears, and metaphase chromosome spreads.

The unique ZytoLight Repeat Subtraction Technique leads to advanced specificity and less background of all our SPEC probes. The CEN probes hybridize to highly repetitive satellite DNA sequences, producing sharp, bright signals specific to each individual chromosome.

ZytoVision has a very wide range of FISH probes. Search by the Chromosome Index, the Gene Index, or by the Indication Index.

 
Product Focus

A uniquely designed ALK/EML4 TriCheck FISH probe for lung cancer diagnosis.

ZytoLight SPEC ALK/EML4 TriCheck Probe

The ZytoLight SPEC ALK/EML4 TriCheck Probe is designed to detect inversions involving the chromosonal region 2p23.1-p23.2 harboring the ALK gene and the chromosonal region 2p21 harboring the EML4 gene. Moreover, using this probe it is possible to discriminate between EML4-ALK inversions and translocations affecting ALK, but not EML4.

 
ZytoLight Kits – Convenient Solutions

For making FISH analysis reliable and user-friendly, all ZytoLight FISH probes can be combined with:

  • ZytoLight FISH-Tissue Implementation Kit for FISH analyses on tissue specimens (Z-2028-5/-20)
  • ZytoLight FISH-Cytology Implementation Kit for FISH analyses on cytology specimens (Z-2099-20)

Both Implementation Kits include all necessary pretreatment solutions, wash buffers and DAPI/Antifade solution and a detailed protocol to perform successful FISH experiments.

 

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