ANCA-associated diseases are caused by vasculitis of the small vessels in which antineutrophil cytoplasmic antibodies (ANCA) can be detected in a patient’s blood.1,2 A rapid diagnosis of ANCA-associated small-vessel vasculitis is critically important because life-threatening injury to organs often develops quickly and can be rapidly mitigated by immunosuppressive therapy.2
Alpha-Gal syndrome, a red meat allergy, is triggered by IgE antibodies targeting galactose-alpha-1,3-galactose, known as ‘alpha-Gal’, found in the meats of non-primate mammals. Tick bites are the primary carrier for this sensitisation. Recognising a potential connection to tick bites can significantly aid the diagnostic process. 1,3
Immuno Concepts: ANCA-L Newsletter – The international testing consensus, assay differences, and sample interpretation support.
This newsletter provides an in-depth overview of the diagnostic systems produced by Immuno Concepts for the detection and differentiation of anti-neutrophil cytoplasmic antibodies (ANCA), which are crucial in diagnosing autoimmune vasculitis. It details various assay systems, including ethanol-fixed and formalin-fixed slides, and ELISA tests for anti-MPO and anti-PR3 antibodies.
Immuno Concepts are leaders in the development of state-of-the-art diagnostic assays for systemic rheumatic diseases.
Immuno Concepts not only pioneered the conversion from rodent tissue to HEp-2 cells for the detection of anti-nuclear antibodies (ANAs) but also overcame one of the main pitfalls of ANA detection with the introduction of HEp-2000®, a patented ANA substrate genetically improved with increased sensitivity for detection of autoantibodies to SS-A/Ro.1
The Immuno Concepts Patient Sample Interpretative Training Series (PSITS) is a program designed as a teaching and training tool for laboratory staff to enhance their knowledge in autoimmune disease testing and links the laboratory results with the clinical diagnosis and interpretation.
LINE Immunoassays are used to qualitatively determine IgG and/or IgM antibodies against gangliosides in human serum.
Products are for Professional/Laboratory use only
We would like to share with you an overview from Thermo Fisher on the Coefficient of Variation (CV) in the EliA™ well DFUs.
Products are for professional/laboratory use only.
Interferons (IFNs) are the first line of defence against viral infections and have important roles in immunosurveillance for malignant cells. IFNs are classified as type I ( IFNε, IFNα2, IFNβ, IFNω), II (IFNɣ), and III (IFNλ1, λ2, λ3), based on the target receptors to which they bind.