ImmunoCAP Tryptase is a well-known clinical marker in explaining severe reactions cause by insect venoms, drugs, or in systemic mastocytosis.
High-baseline tryptase levels can indicate if a person may be predisposed to severe anaphylactic reactions; and precautionary measures, e.g., an epinephrine autoinjector and specific immunotherapy, may be considered.
Typtase and Drug Reactions
- Tryptase levels can assist in finding the cause of a severe reaction which can occur during surgery.
- Measurements of transiently elevated tryptase levels directly after the reaction can help to identify if the reaction was due to mast cell activation.
Tryptase and Venoms
- Tryptase can support the clinical assessment regarding need for therapy in patients being considered for venom-specific immunotherapy after previous reactions to bee and/or wasp stings.
- Tryptase can help guide VIT treatment and in deciding on lifelong treatment.
Typtase and Mastocystosis
- Tryptase baseline levels reflect the mast cell burden in the body.
- Together with clinical findings, ImmunoCAP Tryptase test results can help to rule in or rule out systemic mastocystosis.
- WHO (World Health Organization) minor diagnostic criterion for systemic mastocytosis includes a persistently elevated baseline serum tryptase value above 20 μg/l (1 μg/l = 1 ng/ml).
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