Thermo Fisher – Total IgE Testing

One marker can offer valuable insights across a range of clinical applications.

Allergy assessment often requires multiple pieces of information to build a clearer clinical picture. Total immunoglobulin E (IgE) is a marker that can provide valuable insights across a range of clinical applications.

Thermo Fisher Scientific’s ImmunoCAP™ Total IgE assays quantify circulating IgE in human serum or plasma, aiding the diagnosis of IgE-mediated allergic disorders. Total IgE may be elevated in patients with conditions including asthma and atopic dermatitis.^3,4

More than allergy assessment

The potential clinical utility of Total IgE extends beyond general allergy assessment.

Accurate IgE measurement can help reveal sensitisation associated with high allergen exposure in suspected occupational allergy, including in individuals without an atopic background.⁵˒⁶ Total IgE has also been recognised as a marker to aid the diagnosis of allergic bronchopulmonary aspergillosis (ABPA) and to monitor its progression and response to treatment.¹³˒¹⁴

Total IgE also has a role in the management of patients receiving omalizumab. Baseline serum Total IgE is used to determine omalizumab dosage for specific indications.⁸ For chronic spontaneous urticaria (CSU), international guidelines recommend Total IgE assessment as a basic diagnostic test following clinical history and physical examination.⁹

See the bigger picture

From supporting allergy assessment to specific clinical applications and patient management, Total IgE can provide a valuable piece of the diagnostic picture.

Discover how ImmunoCAP™ Total IgE can support your laboratory and allergy testing workflow.

Some products may not be cleared for use in your country. Please contact your local representative for information about specific product availability.

1. ImmunoCAP Total IgE Directions for Use. 2022; 52-5292-EN/10.
2. ImmunoCAP Total IgE Low Range Directions for Use. 2022; 52-5229-EN/21.
3. Cakanlar FN, et al. Relationship between serum total IgE specific IgE and serum total eosinophil counts in asthma bronchiale patients. World Allergy Organization Journal. 2015;8(1):A25.
4. Poleshuck RTF, et al. Levels of total serum IgE and specific IgE sensitization profile in patients with atopic dermatitis. World Allergy Organ J. 2015;8(1):A142.
5. Hollund BE, et al. Occupational exposure to hairdressing chemicals and immunoglobulin E synthesis. Scand J Work Environ Health. 2002;28(4):264-269.
6. Hossain MA, Islam LN. Effect of occupational exposure on allergic diseases and relationship with serum IgE levels in the tannery workers in Bangladesh. Bioresearch Commun. 2016;2(6):158-163.
7. Xolair [package insert]. South San Francisco (CA): Genentech, Inc.; 2023.
8. Zuberbier T, et al. The international EAACI/GA²LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria. Allergy. 2022;77(3):734-766.
9. Agarwal R, et al. Utility of IgE (total and Aspergillus fumigatus specific) in monitoring for response and exacerbations in allergic bronchopulmonary aspergillosis. Mycoses. 2016;59(1):1-6.
10. Qian H, et al. High level of initial Aspergillus fumigatus-specific IgE links increased risk of exacerbation in allergic bronchopulmonary aspergillosis patients. Respir Res. 2025;26(95):95.
11. Hamilton RG. Accuracy of US Food and Drug Administration-cleared IgE antibody assays in the presence of anti-IgE (omalizumab). J Allergy Clin Immunol. 2006;117(4):759-766.
12. Vuljanić D, et al. Third-party verification of total and specific immunoglobulin E on analyzer Immulite® 2000XPi. Clin Chim Acta. 2020;500:28-33.

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THESE PRODUCTS ARE NOT AVAILABLE FOR PURCHASE BY THE GENERAL PUBLIC.