Generic Assays – Anti-Ganglioside

Last updated: 26th June, 2024

LINE Immunoassays are used to qualitatively determine IgG and/or IgM antibodies against gangliosides in human serum.

Anti-Ganglioside highlights:

  • Serological marker for autoimmune polyneuropathies
  • Diagnostic efficiency through profile diagnostics with 12 antigens
  • Best Performance on the market

Autoimmune neuropathies

Autoimmune neuropathies of the peripheral nervous system are characterized by numerous clinical symptoms which, however, do not differ from those of other neuropathies. Neuropathies of autoimmune origin (13% of all neuropathies) can therefore be misdiagnosed as idiopathic and thus incorrectly treated. The determination of anti-ganglioside antibodies can therefore contribute to the diagnosis of this group of diseases.

  Sulf GM1 GM2 GM3 GM4 GD1a GD1b GD2 GD3 GT1a GT1b GQ1b
GBS/AIDP   IgG     IgM IgG IgG       IgG  
GBS/AMAN & AMSAN IgM IgG     IgM IgG IgG       IgG  
GBS after CMV-Infection   IgM IgM     IgM IgM          
GBS with ataxia             IgG     IgG   IgG
GBS with ONS   IgG       IgG       IgG   IgG
GBS with ophthamoplegia                   IgG   IgG
MFS         IgM   IgG   IgG IgG IgG IgG
Bickerstaff encephalitis                   IgG   IgG
CANOMAD       IgM   IgM IgM IgM IgM IgM IgM IgM
MMN   IgM IgM IgM IgM IgM IgM          
CIDP IgM IgM IgM IgM   IgM IgM          
MN with gammopathy IgM IgM         IgM          

AIDP – acute inflammatoric demyelinating polyneuropathy, AMAN – acute motor axonal neuropathy, AMSAN – acute motor and sensory axonal neuropathy, CANOMAD -chronic ataxic neuropathy ophthalmoplegia IgM paraprotein cold agglutinins disialosyl antibodies, CIDP – chronic inflammatoric demyelinating polyneuropathy, CMV -cytomegalovirus, GBS – Guillain-Barré syndrome, MFS – Miller Fisher syndrome, MMN – multifocal motor neuropathy with conduction blocks, MN – motor neuropathy, ONS -acute paralysis of the oropharyngeal neck and shoulder muscles. Adapted from Conrad et al. 2011.

An Example for Immunpathogenesis – GBS/AMAN

Gangliosides GM1 and GD1a are strongly expressed at the nodes of Ranvier of myelinated axons, where the voltage-gated sodium (Nav) channels are localized. IgG anti-GM1 or anti-GD1a autoantibodies bind to the nodal axolemma, leading to membrane attack complex (MAC) formation. This results in the disappearance of Nav clusters and the detachment of paranodal myelin, which can lead to nerveconduction failure and muscle weak-ness. Axonal degeneration may follow at a later stage. Macrophages subsequently invade from the nodes into the periaxonal space, scavenging the injured axons.


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