Immuno Concepts are leaders in the development of state-of-the-art diagnostic assays for systemic rheumatic diseases.
Immuno Concepts not only pioneered the conversion from rodent tissue to HEp-2 cells for the detection of anti-nuclear antibodies (ANAs) but also overcame one of the main pitfalls of ANA detection with the introduction of HEp-2000®, a patented ANA substrate genetically improved with increased sensitivity for detection of autoantibodies to SS-A/Ro.1
Immuno Concepts: Technical Bulletin 2024 Q4 – PCNA, NuMA, Nuclear Dots
This technical bulletin will review four ANA patterns: PCNA, NuMA, Multiple Nuclear Dots (MND) and Few Nuclear Dots (FND). All four patterns are classified as expert-level patterns by the International Consensus on ANA Patterns (ICAP)2. When encountered in a clinical setting, it’s sufficient to call them under their umbrella categories: pleomorphic (PCNA), mitotic (NuMA), and discrete nuclear dots (MND and FND)2.
Request below the latest 2024 Q4 Immuno Concepts Technical Bulletin.
References:
- https://immunoconcepts.com/
- International Consensus on ANA Patterns. Nomenclature and classification tree. https://anapatterns.org/trees-2021.php (Accessed February 2024).
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