Immuno Concepts are leaders in the development of state-of-the-art diagnostic assays for systemic rheumatic diseases.
Immuno Concepts not only pioneered the conversion from rodent tissue to HEp-2 cells for the detection of anti-nuclear antibodies (ANAs) but also overcame one of the main pitfalls of ANA detection with the introduction of HEp-2000®, a patented ANA substrate genetically improved with increased sensitivity for detection of autoantibodies to SS-A/Ro.1
Immuno Concepts: Technical Bulletin 2025 Q2 – How to Structure Testing: Optimal Screening, and Relayed Assays
This technical bulletin emphasises the importance of personalised autoimmune diagnostics, highlighting that no two patients are alike and that antibody behaviour can vary significantly. It advocates for strategic reflex testing based on sensitivity and specificity to improve diagnostic accuracy.
The bulletin outlines optimal workflows using Immuno Concepts products, including HEp-2000® slides for initial ANA screening and specific follow-up assays like the nDNA test for homogeneous patterns, RELISA® ENA for speckled patterns, and HISTOFLUOR® Rodent LKS slides for cytoplasmic staining. Ultimately, it underscores that combining multiple test results provides clinicians with a clearer, more reliable understanding of patient conditions.
Request below the latest 2025 Q2 Immuno Concepts Technical Bulletin.
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