Creating value and contributing to improved healthcare outcomes by connecting innovative manufacturers with Australasian customers

Theradiag LISA TRACKER for determination of ustekinumab in Crohn’s disease

Products are for professional/laboratory use only.

Ustekinumab Serum Trough Levels May Identify Suboptimal Responders to Ustekinumab in Crohn’s Disease. Painchart C, Brabant S et al; Dig Dis Sci. 2019 Oct 10.

Abstract

Aim
The aim of this study was to evaluate the association between serum ustekinumab (UST) trough levels and response to induction and maintenance UST treatment in refractory Crohn’s Disease (CD) patients.

Methods
We performed a prospective study including CD patients who received UST from September 2015 to January 2017. Patients received 90 mg of UST subcutaneously at weeks 0, 4, and 12, then every 8 weeks. Two cohorts of patients were analyzed: an induction cohort and a maintenance cohort. We evaluated clinical, biological, and imaging/endoscopic response to UST treatment. UST trough levels and anti-UST antibodies were dosed at weeks 12 and 28 in the induction cohort, and at a single time point in the maintenance cohort.

Results
Forty-nine patients were enrolled in the maintenance cohort. Mean concentrations of UST were 1.88 ± 1.40 μg/mL. UST trough levels were not significantly different in patients with or without clinical, biological, or imaging/endoscopic responses to UST treatment (p > 0.11). Twenty-three consecutive patients were included in the induction cohort. At week 12, mean UST concentrations were 1.45 ± 1.15 μg/mL. Patients with a biological response to UST treatment had significant higher serum UST trough concentration (median 1.72 μg/mL) than non-responders (median 0.56 μg/mL, p = 0.02). A UST  trough level ≥ 1.10 μg/mL at week 12 was associated with a biological response to UST treatment at 6 months.

Conclusion
UST trough levels were associated with a biological response at the end of the induction phase. In patients with low levels of UST, optimization treatment may be necessary to obtain a sustained response.

Read Abstract

Pubmed>

Discover Theradiag LISA TRACKER

Click Here >

Request a quote

Contact Us >



Request a Quote

Request Quote

Recent Posts

Thermo Fisher – Coeliac Disease Testing

Managing IgA-deficient samples in coeliac disease testing – antibody testing to support the diagnosis of coeliac disease. Celiac disease is a lifelong condition in which…

Read full article

Thermo Fisher – Mould Allergy Testing

Allergy to mould and successful AIT | Discover the connection ImmunoCAP® Allergen Components help you identify appropriate allergens for improved AIT outcomes. (more…)

Read full article

IBL – Neurodegeneration Research*

THE HALLMARKS OF NEURODEGENERATION. Discover IBL’s broad range of solutions optimised for neurodegeneration biomarkers measurement, designed to keep your research at the forefront of the…

Read full article