The MILLIPLEX® Human Cell Health Magnetic Bead Panel is a fixed 16-plex assay that explains overall cell health. Each analyte is a marker for a particular cellular function.
Analytes: CHOP, Cyclin B1, Complex IV, Ki67, LC3B, HIF-1a, Polyubiquitin K48-linkage, HSP70, cleaved PARP, and GRP78 and phosphorylated eIF4B (Ser422), NF-κB (Ser536), Histone H2A.x (Ser139), Histone H3 (Ser10), p53 (Ser15), and RNA Pol II (Ser2)
Species reactivity: Human
| Analyte/Biomarker | Cellular Function |
| Histone H3 (Ser10) | Chromatin condensation |
| RNA Pol II (Ser2) | mRNA synthesis |
| Cleaved PARP | Apoptosis |
| Phosphorylated eIF4B (Ser422) | Protein synthesis |
| Complex IV | OXPHOS |
| Polyubiquitin K48-linkage | Protein degradation |
| LC3B | Autophagy |
| HIF-1a | Oxidative stress |
| HSP70 | General stress |
| Histone H2A.x (Ser139) | DNA repair |
| CHOP | Protein secretion |
| Cyclin B1 | Cell cycle (G1/S) |
| GRP78 | ER stress |
| p53 (Ser15) | DNA damage |
| NF-KB (Ser536) | Inflammatory Response |
| Ki-67 | Cell Viability and Proliferation |
APPLICATIONS: MILLIPLEX Human Cell Health Magnetic Bead Panel
- Drug development and toxicology
Cell health analysis is widely used to assess the toxicity of new drug candidates by evaluating how they affect cell viability, proliferation, and apoptosis. This helps identify potentially harmful compounds early in the development process. Can also be integrated into high-throughput screening platforms to quickly assess the effects of thousands of compounds on cell viability and function. - Cell cycle studies
Monitoring cell health through the cell cycle (e.g., using markers like Ki-67) is critical for understanding how cells divide and grow, which has applications in cancer, tissue development, and regenerative medicine. - Cancer research
Cell health assays are used to monitor how cancer cells respond to treatments like chemotherapy, radiotherapy, or immunotherapy. This helps researchers identify effective treatments and understand resistance mechanisms. Can also be used to study apoptosis and cell death markers. - Stem cell research and cell therapy
Used to monitor the ability of stem cells to differentiate into specific lineages and proliferate. Healthy cells are crucial for regenerative medicine applications. To check transplanted cells are viable and functional for successful cell therapies. - Aging research
Cell health analysis helps study cellular senescence, the process by which cells lose their ability to divide and function. This is critical in aging research to understand age-related diseases and potential anti-aging interventions.
THESE PRODUCTS ARE NOT AVAILABLE FOR PURCHASE BY THE GENERAL PUBLIC.
