Streamline Your Toxicity Testing with MILLIPLEX® Multiplex Assays
Toxicity studies are critical when it comes to evaluating drug safety and how the drug molecule interacts with key organs.
Bead-based multiplex toxicity assays enable a precise, multiparametric analysis of toxicity and its underlying processes. MILLIPLEX multiplex toxicity biomarker assay kits enable researchers to simultaneously quantify dozens of toxicity analytes across several species (including rat, mouse, porcine, canine, and feline models). For example, these assays can analyse specific toxicities including:
- Drug-induced liver injury
- Kidney toxicity
- Genotoxicity
- Early-stage toxicity testing evaluating effects of compounds on cell signaling pathways
Explore our popular MILLIPLEX multiplex toxicity assays below.
Kidney Toxicity
Detecting qualified kidney toxicity biomarkers, in contrast to traditional BUN and serum creatinine (SCr) tests, can enable early detection and localisation of kidney damage, which are crucial for the accurate assessment of toxicity.
| Product Number | Product Name | The analytes available for this multiplex kit are: |
| RKTX1MAG-37K | MILLIPLEX Rat Kidney Toxicity Magnetic Bead Panel 1 – Toxicity Multiplex Assay | Clusterin, GSTα, IP-10, KIM-1, OPN – Osteopontin, TIMP-1, VEGF. |
| RKTX2MAG-37K | MILLIPLEX Rat Kidney Toxicity Magnetic Bead Panel 2 – Toxicity Multiplex Assay | Albumin, AGP, ß2M, Cystatin C, EGF, Lipocalin-2/NGAL. |
| CKT1MAG-97K | MILLIPLEX Canine Kidney Toxicity Expanded Magnetic Bead Panel 1, CKT1MAG-97K | Clusterin, Cystatin C, Kidney Injury Molecule-1 (KIM-1), IL-8, Lipocalin-2/NGAL, MCP-1, Osteopontin (OPN). |
| CKT2MAG-97K | MILLIPLEX Canine Kidney Toxicity Panel 2 – Toxicity Multiplex Assay | Albumin, ß-2-microglobulin (B2M), Trefoil Factor 3 (TFF- 3), Retinol Binding Protein 4 (RBP4). |
| MKI1MAG-94K | MILLIPLEX Mouse Kidney Injury Magnetic Bead Panel 1 – Toxicity Multiplex Assay | B-2-Microglobulin, IP-10, KIM-1, Renin, TIMP-1, VEGF (for urine samples) or IP-10, KIM-1, Renin, and TIMP-1. |
| MKI2MAG-94K | MILLIPLEX Mouse Kidney Injury Magnetic Bead Panel 2 – Toxicity Multiplex Assay | Clusterin, Cystatin C, EGF, Lipocalin-2/NGAL, Osteopontin (OPN) (for urine samples) or Clusterin, Cystatin C, Lipocalin- 2/NGAL, Osteopontin (OPN) |
| HKI1MAG-99K | MILLIPLEX Human Kidney Injury Magnetic Bead Panel 1 – Toxicity Multiplex Assay | Calbindin, Collagen IV, Fatty Acid Binding Protein 1 (FABP1), GSTa, IP-10, Kidney Injury Molecule-1 (KIM-1), Renin, TFF-3, TIMP- 1. |
| HKI2MAG-99K | MILLIPLEX Human Kidney Injury Magnetic Bead Panel 2 – Toxicity Multiplex Assay | a-1-Microglobulin, Albumin, Clusterin, Cystatin C, EGF, Lipocalin-2/NGAL, and Osteopontin (OPN). |
| HKI3MAG-99K | MILLIPLEX Human Kidney Injury Magnetic Bead Panel 3 – Toxicity Multiplex Assay | B-2-Microglobulin (B2M), Retinol Binding Protein 4 (RBP4), Uromodulin. |
| HKI4MAG-99K | MILLIPLEX Human Kidney Injury Magnetic Bead Panel 4 – Toxicity Multiplex Assay | EGF, FABP1, IP-10, KIM-1, Osteopontin (OPN), PTH and Renin. |
| HKI5MAG-99K | MILLIPLEX Human Kidney Injury Magnetic Bead Panel 5 – Toxicity Multiplex Assay | α-1-Microglobulin, Collagen IV, Lipocalin-2/NGAL, Osteoactivin, TIMP-1, Uromodulin. |
| HKI6MAG-99K | MILLIPLEX Human Kidney Injury Magnetic Bead Panel 6 – Toxicity Multiplex Assay | β-2-Microglobulin (β2M), Clusterin, Cystatin C, RBP4. |
Liver Injury
Biomarkers like ARG1 and SDH are hepatocellular and hepatobiliary enzymes that are released into circulation upon the occurrence of liver injury.
| Product Number | Product Name | The analytes available for this multiplex kit are: |
| RLI1MAG-92K | MILLIPLEX Rat Liver Injury Panel – Toxicity Multiplex Assay | GSTα, 5′-NT/CD73, GOT1, ARG1 and SDH |
| HLINJMAG-75K | MILLIPLEX Human Liver Injury Magnetic Bead Panel – Toxicity Multiplex Assay | GSTα, 5′-NT/CD73, GOT1, ARG1 and SDH |
Vascular Injury
In addition to heart rate and mean arterial blood pressure, measuring key proteins in smooth muscle, endothelial cells, and immune-mediated cells may yield promising biomarkers for vascular injury.
| Product Number | Product Name | The analytes available for this multiplex kit are: |
| RV1MAG-26K | MILLIPLEX Rat Vascular Injury Magnetic Bead Panel 1 – Toxicity Multiplex Assay | Caveolin-1, CINC-1/GRO/KC, CTGF (Connective Tissue Growth Factor), IL-6, MCP-1, PAI-1 (total), TIMP-1, TNFα, VEGF. |
| RV2MAG-26K | MILLIPLEX Rat Vascular Injury Magnetic Bead Panel 2 – Toxicity Multiplex Assay | Adiponectin, sE-Selectin, and sICAM-1. |
| RV3MAG-26K | MILLIPLEX Rat Vascular Injury Magnetic Bead Panel 3 – Toxicity Multiplex Assay | α-1-Acid Glycoprotein (AGP), α-2-Macroglobulin (A2M), Haptoglobin. |
Endocrine Disruptor Chemicals (EDC)
Reproductive, adrenal, thyroid, and pituitary hormone levels and their functions in humans and animals can be altered with exposure to EDCs. In vitro cell assays and in vivo models for various species may be used to assess the effects of chemical exposure.
| Product Number | Product Name | The analytes available for this multiplex kit are: |
| MSHMAG-21K | MILLIPLEX Multi-Species Hormone Magnetic Bead Panel | The Multi-Species Hormone Panel, using the Luminex xMAP technology, enables the simultaneous analysis of 5 steroid/thyroid biomarkers in human serum, plasma and cell culture samples. |
| RPTMAG-86K | MILLIPLEX Rat Pituitary Magnetic Bead Panel – Endocrine Multiplex Assay | ACTH, BDNF, FSH, GH, LH, Prolactin, TSH. |
| MPTMAG-49K | MILLIPLEX Mouse Pituitary Magnetic Bead Panel – Endocrine Multiplex Assay | ACTH, BDNF, FSH, GH, Prolactin, TSH, LH. |
| HPTP1MAG-66K | MILLIPLEX Human Pituitary Magnetic Bead Panel 1 – Endocrine Multiplex Assay | The Human Pituitary Panel 1, using the Luminex xMAP technology, enables the simultaneous analysis of 7 protein biomarkers in human serum, plasma and cell culture samples. |
| CANPIT-96K | MILLIPLEX Canine Pituitary Expanded Panel – Endocrine Multiplex Assay | ACTH, FSH, GH, TSH, LH, & Prolactin. |
| NHPPT1MG-46K | MILLIPLEX Non-Human Primate Pituitary Magnetic Bead Panel 1 – Endocrine Multiplex Assay | ACTH, AGRP, CNTF, FSH, GH, LH, TSH. |
Genotoxicity
Genotoxicity assays help researchers assess the effects of DNA damage.
| Product Number | Product Name | The analytes available for this multiplex kit are: |
| 48-621MAG | MILLIPLEX DNA Damage/Genotoxicity Magnetic Bead Panel – Cell Signaling Multiplex Assay | ATR, Chk1, Chk2, H2A.X, p53, MDM2 and p21. |
THESE PRODUCTS ARE NOT AVAILABLE FOR PURCHASE BY THE GENERAL PUBLIC.
