Transform Your Drug Delivery Strategy with PLGA Nanoparticles
Applications of PLGA Nanoparticles
Poly (D,L-lactide-co-glycolic acid) (PLGA) is a biodegradable polymer commonly used to make particles for in vivo studies and is generally regarded as safe. PLGA is approved by both the US Food and Drug Administration (FDA) and European Medicine Agency (EMA) for use in vaccines, drug delivery, and tissue engineering.1,2
PLGA particles can be loaded with either hydrophobic drugs or hydrophilic peptides/proteins, encapsulating the active compound and protecting it from proteolytic degradation. Moreover, the surface of the nanoparticles can be chemically modified for specific tropism or molecule release, or to evade the reticuloendothelial system (RES). Successful development of PLGA nanoparticles as a delivery system requires precise loading and encapsulation of active ingredients, followed by their controlled release.
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