TriLink – CleanCap M6 mRNAs

Last updated: 01st May, 2024

THESE PRODUCTS ARE NOT AVAILABLE FOR PURCHASE BY THE GENERAL PUBLIC.

Three mRNA designs for diverse projects. TriLink offers premade mRNAs in three designs: CleanCap® mRNAs, CleanCap mRNAs (5moU), and CleanCap M6 mRNAs (N1MePsU). They all contain an optimal 5′ Cap 1 found in higher eukaryotes for their functionality and stability.

Their 5′ UTR is synthetic, containing a strong Kozak sequence, designed to promote efficient translation while the 3′ UTR is derived from mouse alpha-globin. Their key differences lie in the type of CleanCap analog used and the base compositions, which may affect their protein expression and immunogenicity. View the three TriLink CleanCap options in the table below.

  CleanCap mRNAs CleanCap mRNAs (5moU) CleanCap M6 mRNAs (N1MePsU)

Expression system

Mammalian

Mammalian

Mammalian

5′ cap

Cap 1

Cap 1

Cap 1

Cap analog

CleanCap AG

CleanCap AG

CleanCap M6

5′ and 3′ UTRs

Included

Included

Included

Poly(A) tail

120 nt

120 nt

120 nt

Sequence composition

Unmodified uridines

Uridines substituted with 5-methoxyuridine

Uridines substituted with N1-methylpseudouridines

Protein expression

High

High

Highest

Immunogenicity

Normal

Reduced

Lowest


Six new CleanCap mRNA constructs

The new constructs are available in three sizes (100 µg, 1 mg, 5 mg) and bulk. These constructs are listed in the table below.

Gene Cat no. / ordering page  Supporting documents

Enhanced green fluorescent protein (EGFP) 

L-8101 

Product insert 

Firefly luciferase (FLuc) 

L-8102 

Product insert 

mCherry 

L-8103 

Product insert 

CRISPR Associated Protein 9 (Cas9) 

L-8106 

Product insert 

Erythropoietin (EPO) 

L-8109 

Product insert 

Cre recombinase (Cre) 

L-8111 

Product insert 

 


Learn more about the Trilink’s mRNAs

Learn more about TriLink CleanCap mRNAs

Download the flyer >

View product FAQs on all new catalogue TriLink CleanCap M6 mRNAs

Learn more >



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