Are you using Asuragen’s AmplideX FMR1 kit?

Last updated: 21st March, 2024


How is your lab performing FMR1 gene testing?

Use the kit referenced in over 30 peer-reviewed publications and used in over 200 laboratories around the world. Asuragen’s AmplideX® PCR/CE FMR1 Reagents are globally recognised as best-in-class for the assessment of CGG repeats in the FMR1 gene.

AmplideX PCR/CE FMR1 Kit is an in vitro diagnostic (IVD) device for use in clinical laboratories for the detection of the CGG repeats in the Fragile X Messenger Ribonucleoprotein 1 (FMR1) gene. The device is intended to aid in the diagnosis of fragile X syndrome and fragile X-associated disorders, e.g. tremor and ataxia syndrome (FX-TAS) and primary ovarian insufficiency (FXPOI), through the determination of CGG repeat length up to 200 CGG and detection of alleles greater than 200 CGG. The kit provides a PCR-only approach based on Triplet Repeat Primed PCR (TP-PCR) design to reliably amplify and detect all alleles including Full Mutations.

AmplideX PCR/CE FMR1 Kit has created an easy-to-use, accessible, high-performance method for laboratories to reliably analyze CGG repeats and detect interrupting AGG sequences in the FMR1 gene.

Reduced Complexity

Ease-of-analysis of the FMR1 gene has been simplified through:

  • Implementation of proprietary PCR solution for amplifying GC-rich regions
  • Automation of result calling using AmplideX PCR/CE FMR1 Reporter

Optimized Workflow

Valuable operator hands-on time has been significantly reduced through:

  • Direct injection of PCR products (no PCR clean up) in to Capillary Electrophoresis platforms
  • Decreased need for Southern blot analysis (up to 50 fold)
  • End-to-end solution for FMR1 analysis including all necessary reagents and software

Quality Performance

Performing FMR1 Analysis with Greater Sensitivity and Accuracy:

  • Detection of all allele expansions, including low abundance full mutation size mosaics with up to at least 1300 CGG repeats
  • Up to 875 fold more sensitive than Southern blot1
  • Resolution of female homozygous and heterozygous samples and indication of interrupting AGG sequences
  • Proven performance as indicated by more than 30 peer-reviewed publications

Read more about Asuragen's FMR1 Kit

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