Spotlight on: ERG (EP1111)

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Thythroblast transformation specific related gene, also known as ERG, is a transcription factor associated with endothelial differentiation as well as prostate malignancy. Studies have shown that anti-ERG compares favorably to CD31 and CD34 antibodies in terms of sensitivity and specificity in the identification of angiosarcoma and hepatic angiosarcoma1-2, and hemangioendotheliomas2. In epithelial tumors, ERG immunostaining shows very high specificity (99%) for prostate carcinoma3.

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