Spotlight on: ERG (EP1111)
Thythroblast transformation specific related gene, also known as ERG, is a transcription factor associated with endothelial differentiation as well as prostate malignancy. Studies have shown that anti-ERG compares favorably to CD31 and CD34 antibodies in terms of sensitivity and specificity in the identification of angiosarcoma and hepatic angiosarcoma1-2, and hemangioendotheliomas2. In epithelial tumors, ERG immunostaining shows very high specificity (99%) for prostate carcinoma3.
Benefits of ERG:
- In vitro diagnostic
- Nuclear visualization
- ERG protein expression is more specific than AMACR (P504s) staining for prostate carcinoma.3
- ERG transcription factor is a preferred option to the cytoplasmic CD31 and CD34 for labeling both hemangiomas and lymphangiomas.5
- The Kim et al paper concludes that “the present study demonstrated a superiority with ERG immunostaining and indicated that ERG is a promising panendothelial marker that might help pathologists increase LVI detection and decrease interobserver variability in LVI diagnosis”.4
- ERG has the sensitivity of a rabbit antibody with the specificity and cleanliness of a monoclonal antibody for a strong signal to noise ratio.
- 1. Sullivan HC, et al. J Clin Pathol. 2015; 68:44-50
- 2. Requena L, et al. JAMA Dermatol. 2013; 149:459-65
- 3. Tomlins SA, et al. Arch Pathol Lab Med. 2012; 136:935-46
- 4. Kim S, et al. Korean J Pathol. 2013;47:355-64
- 5. Miettinen M, et al. Am J Surg Pathol. 2011; 35:432-41.
* Note in the background, endothelial cells are stained positive as internal positive control.
|0.1 ml, concentrate||434R-14|
|0.5 ml, concentrate||434R-15|
|1 ml, concentrate||434R-16|
|1 ml, concentrate||434R-17|
|7 ml, concentrate||434R-18|
|Positive control slides||434S|