Spotlight on: ERG (EP1111)

Last updated: 25th November, 2015

Thythroblast transformation specific related gene, also known as ERG, is a transcription factor associated with endothelial differentiation as well as prostate malignancy. Studies have shown that anti-ERG compares favorably to CD31 and CD34 antibodies in terms of sensitivity and specificity in the identification of angiosarcoma and hepatic angiosarcoma1-2, and hemangioendotheliomas2. In epithelial tumors, ERG immunostaining shows very high specificity (99%) for prostate carcinoma3.

Benefits of ERG:

    • In vitro diagnostic
    • Nuclear visualization
    • ERG protein expression is more specific than AMACR (P504s) staining for prostate carcinoma.3
    • ERG transcription factor is a preferred option to the cytoplasmic CD31 and CD34 for labeling both hemangiomas and lymphangiomas.5
    • The Kim et al paper concludes that “the present study demonstrated a superiority with ERG immunostaining and indicated that ERG is a promising panendothelial marker that might help pathologists increase LVI detection and decrease interobserver variability in LVI diagnosis”.4
    • ERG has the sensitivity of a rabbit antibody with the specificity and cleanliness of a monoclonal antibody for a strong signal to noise ratio.

References

    • 1. Sullivan HC, et al. J Clin Pathol. 2015; 68:44-50
    • 2. Requena L, et al. JAMA Dermatol. 2013; 149:459-65
    • 3. Tomlins SA, et al. Arch Pathol Lab Med. 2012; 136:935-46
    • 4. Kim S, et al. Korean J Pathol. 2013;47:355-64
    • 5. Miettinen M, et al. Am J Surg Pathol. 2011; 35:432-41.

cells * Note in the background, endothelial cells are stained positive as internal positive control.


Ordering Information:

Volume Part No.
0.1 ml, concentrate 434R-14
0.5 ml, concentrate 434R-15
1 ml, concentrate 434R-16
1 ml, concentrate 434R-17
7 ml, concentrate 434R-18
Positive control slides 434S
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