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Thythroblast transformation specific related gene, also known as ERG, is a transcription factor associated with endothelial differentiation as well as prostate malignancy. Studies have shown that anti-ERG compares favorably to CD31 and CD34 antibodies in terms of sensitivity and specificity in the identification of angiosarcoma and hepatic angiosarcoma1-2, and hemangioendotheliomas2. In epithelial tumors, ERG immunostaining shows very high specificity (99%) for prostate carcinoma3.
Benefits of ERG:
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- In vitro diagnostic
- Nuclear visualization
- ERG protein expression is more specific than AMACR (P504s) staining for prostate carcinoma.3
- ERG transcription factor is a preferred option to the cytoplasmic CD31 and CD34 for labeling both hemangiomas and lymphangiomas.5
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- The Kim et al paper concludes that “the present study demonstrated a superiority with ERG immunostaining and indicated that ERG is a promising panendothelial marker that might help pathologists increase LVI detection and decrease interobserver variability in LVI diagnosis”.4
- ERG has the sensitivity of a rabbit antibody with the specificity and cleanliness of a monoclonal antibody for a strong signal to noise ratio.
References
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- 1. Sullivan HC, et al. J Clin Pathol. 2015; 68:44-50
- 2. Requena L, et al. JAMA Dermatol. 2013; 149:459-65
- 3. Tomlins SA, et al. Arch Pathol Lab Med. 2012; 136:935-46
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- 4. Kim S, et al. Korean J Pathol. 2013;47:355-64
- 5. Miettinen M, et al. Am J Surg Pathol. 2011; 35:432-41.
* Note in the background, endothelial cells are stained positive as internal positive control.
Ordering Information:
| Volume | Part No. |
|---|---|
| 0.1 ml, concentrate | 434R-14 |
| 0.5 ml, concentrate | 434R-15 |
| 1 ml, concentrate | 434R-16 |
| 1 ml, concentrate | 434R-17 |
| 7 ml, concentrate | 434R-18 |
| Positive control slides | 434S |
