Spotlight on NKX3.1

NKX3.1 is a prostate-specific homeobox gene protein whose expression is predominantly localized to prostate epithelium. It acts as a transcription factor involved in prostate development. Anti-NKX3.1 labels prostate epithelium, both malignant and benign, with a nuclear visualization. Studies have shown that NKX3.1 immunostaining compares favorably to PSA immunostaining in sensitivity of metastatic prostate adenocarcinoma.1 NKX3.1 is recommended to be included in a diagnostic panel with PSA, PSAP, cytokeratin 34betaE12, and GATA3.2

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