NKX3.1

Spotlight on NKX3.1

Last updated: 04th February, 2016

NKX3.1 is a prostate-specific homeobox gene protein whose expression is predominantly localized to prostate epithelium. It acts as a transcription factor involved in prostate development. Anti-NKX3.1 labels prostate epithelium, both malignant and benign, with a nuclear visualization. Studies have shown that NKX3.1 immunostaining compares favorably to PSA immunostaining in sensitivity of metastatic prostate adenocarcinoma.1 NKX3.1 is recommended to be included in a diagnostic panel with PSA, PSAP, cytokeratin 34betaE12, and GATA3.2

Benefits of Rabbit Monoclonal NKX3.1:

  • In vitro diagnostic
  • Nuclear visualization
  • A study conducted by Gurel et al. shows that NKX3.1 is more sensitive than prostate specific antigen (PSA) for metastatic prostate carcinoma.1
  • NKX3.1 has a 99.7% specificity for prostate.1
  • NKX3.1 IHC is cited in the best practices recommendations for prostate in the International Society of Urologic Pathology consensus conference.2

References:
1. Gurel B, et al. Am J Surg Pathol. 2010; 34:1097-105.
2. Epstein JI, et al. Am J Surg Pathol. 2014; 38:e6-e19.

Photo Information:
Top: Rabbit monoclonal anti-NKX3.1 stains the nuclei of benign prostatic glandular epithelium.
Center: Rabbit monoclonal anti-NKX3.1 strongly labels tumor cell nuclei in prostate carcinoma.
Bottom: NKX3.1 is not expressed by bladder.

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