ROS1 is a receptor tyrosine kinase (RTK) encoded by the ROS1 gene. Genetic rearrangements can occur with many different partner genes.
More recently, the detection of ROS1 by IHC on formalin-fixed, paraffin-embedded specimens, together with FISH for detection of translocations or fusions, is being implemented in routine use for diagnosis of non-small cell carcinoma of the lung.
The HistoCyte ROS1 control consists of two cell lines: one with a SLC34A2-ROS1 translocation and resulting fusion protein; the other has no translocation and therefore no ROS1 protein expressed.
Along with the ALK-Lung (EML4-ALK) Analyte Control and PD-L1 Analyte ControlDR, the ROS1 Analyte Control further adds to HistoCyte’s non-small cell lung carcinoma range of biomarker controls.
Abacus dx is the exclusive distributor for HistoCyte in Australia only.
