Cell Marque Dermatopathology

Novel Dermatopathology Markers

Last updated: 03rd February, 2022

Products are for professional/laboratory use only.

We are pleased to highlight the Novel Dermatopathology Markers available from Cell Marque.

SOX-10 (EP268)
Rabbit monoclonal SOX-10 (EP268) has shown to be a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. SOX-10 nuclear expression is seen in 97% of melanomas and 49% of malignant peripheral nerve sheath tumors, whereas S100 protein is expressed in only 91% of melanomas and 30% of malignant peripheral nerve sheath tumors.1 SOX-10 expression is also found in metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not in other lymph node components such as dendritic cells which usually express S100 protein. Anti-SOX-10 is also a useful marker in detecting both the in situ and invasive components of desmoplastic melanoma.

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CD4 (EP204)
Rabbit monoclonal CD4 is expressed on the surface of T-helper/regulatory T cells, monocytes, macrophages, and dendritic cells. Anti-CD4 is used in the immunophenotyping of lymphoproliferative disorders including cutaneous lymphomas such as CD4+ mycosis fungoides.

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Adipophilin (polyclonal)
Adipophilin is an antibody reactive against a protein on the surface of intracellular lipid droplets found in sebocytes. Adipophilin is highly sensitive, specific, and is useful when differentiating sebaceous neoplasms from squamous cell and basal cell carcinomas. A study by MD Anderson Cancer Center showed that adipophilin immunohistochemistry showed higher sensitivity than Oil Red O in detecting intracellular lipids in sebaceous carcinomas.

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