Spotlight on STAT6 (EP325)

Last updated: 01st August, 2017

Solitary fibrous tumors (SFTs) are rare tumors of mesenchymal origin that often originate in the pleura. 

They are formerly known as hemangiopericytomas, though that term is rarely used by soft tissue pathologists now.  Most SFTs are benign, but a small percentage (between 12-22%) are malignant.1 Typically, SFTs universally express CD34, which is sensitive but not specific for these neoplasms.

Recently, it was discovered that a NAB2-STAT6 gene fusion on chromosome region 12q13 was found to be consistently present in SFTs. This fusion is not easily detected by molecular tests such as FISH; however, nuclear expression of anti-STAT6 via immunohistochemistry (IHC) is sensitive and specific for SFTs. This trait suggests that rabbit monoclonal STAT6 (EP325) is a highly specific and sensitive IHC marker for differential diagnosis of SFTs.2

Benefits of Rabbit Monoclonal STAT6 from Cell Marque™:

• For in vitro diagnostic use
• Differentiates solitary fibrous tumors from fibrosarcoma, sarcomatoid mesotheliomas, malignant peripheral nerve sheath tumors, spindle cell carcinomas and other mimics
• Literature cites high specificity and sensitivity of STAT6 for SFTs.2
• Nuclear transcription factor for easily interpreted staining

Ordering Information:

0.1 ml concentrate – 426R-14
0.5 ml concentrate – 426R-15
1 ml concentrate – 426R-16
1 ml prediluted – 426R-17
7 ml prediluted – 426R-18
Positive control slides – 426S

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References:

1.  Robinson LA. Cancer Control. 2006 Oct; 13(4):264-9.
2. Doyle LA, et al. Mod Pathol. 2014 Mar; 27(3):390-5.

 

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