Cell Marque – Mouse Monoclonal Antibody HMB-45 + MART-1 + Tyrosinase Mouse Monoclonal Antibody

Last updated: 22nd May, 2024

Anti-HMB45 is a marker that reacts with antigens present on immature melanosomes. MART-1, or Melan A, is a melanocyte differentiation antigen in melanocytes of normal skin, retina, nevi, and most melanomas.

Tyrosinase is an enzyme involved in the biosynthesis of melanin expressed in epidermal melanocytes, pigmented epithelia of the eye, and most melanomas. Anti-HMB45/MART-1/Tyrosinase reactivity in melanomas makes this combination a useful immunohistochemical reagent for identifying melanomas and melanocytic lesions.1-9


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  1. Orchard G. Evaluation of melanocytic neoplasms: application of a pan-melanoma antibody cocktail. Br J Biomed Sci. 2002; 59:196-202.
  2. Gupta D, et al. Vaginal melanoma: a clinicopathologic and immunohistochemical study of 26 cases. Am J Surg Pathol. 2002; 26:1450-7.
  3. Prasad ML, et al. Expression of melanocytic differentiation markers in malignant melanomas of the oral and sinonasal mucosa. Am J Surg Pathol. 2001; 25:782-7
  4. Yaziji H, et al. Immunohistochemical markers of melanocytic tumors. In J Surg Pathol. 2003; 11:11-5.
  5. Shidham VB, et al. Improved immunohistochemical evaluation of micrometastases in sentinel lymph nodes of cutaneous melanoma with ‘MCW melanoma cocktail’–a mixture of monoclonal antibodies to MART-1, Melan-A, and tyrosinase. BMC Cancer. 2003; 3:15.
  6. Perez RP, et al., Expression of melanoma inhibitory activity in melanoma and nonmelanoma tissue specimens. Hum Pathol. 2000; 31:1381-8.
  7. Hoang MP, et al. Recurrent melanocytic nevus: a histologic and immunohistochemical evaluation. J Cutan Pathol. 2001; 28:400-6.
  8. Baidsen BL, et al. HMB-45 immunohistochemical staining of sentinel lymph nodes: a specific method for enhancing detection of micrometastases in patients with melanoma. Am J Surg Pathol. 2000; 24:1140-6.
  9. Vaggelli L, et al Radioisotopic lymphatic mapping of the sentinel node in melanoma: importance of immunohistochemistry. Tumori. 2000; 86:346-8.


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