Making a difference to the people we help treat by creating value and improving healthcare outcomes through connecting innovative manufacturers with Australasian customers.

Cell Marque – Mouse Monoclonal Antibody HMB-45 + MART-1 + Tyrosinase Mouse Monoclonal Antibody

Anti-HMB45 is a marker that reacts with antigens present on immature melanosomes. MART-1, or Melan A, is a melanocyte differentiation antigen in melanocytes of normal skin, retina, nevi, and most melanomas.

Tyrosinase is an enzyme involved in the biosynthesis of melanin expressed in epidermal melanocytes, pigmented epithelia of the eye, and most melanomas. Anti-HMB45/MART-1/Tyrosinase reactivity in melanomas makes this combination a useful immunohistochemical reagent for identifying melanomas and melanocytic lesions.1-9

 


View the list of Cell Marque 25mL Antibodies

Learn more >

References

  1. Orchard G. Evaluation of melanocytic neoplasms: application of a pan-melanoma antibody cocktail. Br J Biomed Sci. 2002; 59:196-202.
  2. Gupta D, et al. Vaginal melanoma: a clinicopathologic and immunohistochemical study of 26 cases. Am J Surg Pathol. 2002; 26:1450-7.
  3. Prasad ML, et al. Expression of melanocytic differentiation markers in malignant melanomas of the oral and sinonasal mucosa. Am J Surg Pathol. 2001; 25:782-7
  4. Yaziji H, et al. Immunohistochemical markers of melanocytic tumors. In J Surg Pathol. 2003; 11:11-5.
  5. Shidham VB, et al. Improved immunohistochemical evaluation of micrometastases in sentinel lymph nodes of cutaneous melanoma with ‘MCW melanoma cocktail’–a mixture of monoclonal antibodies to MART-1, Melan-A, and tyrosinase. BMC Cancer. 2003; 3:15.
  6. Perez RP, et al., Expression of melanoma inhibitory activity in melanoma and nonmelanoma tissue specimens. Hum Pathol. 2000; 31:1381-8.
  7. Hoang MP, et al. Recurrent melanocytic nevus: a histologic and immunohistochemical evaluation. J Cutan Pathol. 2001; 28:400-6.
  8. Baidsen BL, et al. HMB-45 immunohistochemical staining of sentinel lymph nodes: a specific method for enhancing detection of micrometastases in patients with melanoma. Am J Surg Pathol. 2000; 24:1140-6.
  9. Vaggelli L, et al Radioisotopic lymphatic mapping of the sentinel node in melanoma: importance of immunohistochemistry. Tumori. 2000; 86:346-8.

THESE PRODUCTS ARE NOT AVAILABLE FOR PURCHASE BY THE GENERAL PUBLIC.



Request a Quote

Request Quote

Recent Posts

Nikon ECLIPSE Ui – Educate With Ease

Traditional microscopes, although powerful, have limitations that can hinder learning. Enter the Nikon ECLIPSE Ui, a digital upright microscope designed to transform how microscopy is taught…

Read full article

Cell Marque – Cyclin D1 IHC Solutions

Cyclin D1 Antibodies deliver diagnostic confidence Cell Marque™ Offers Both SP4 and EP12 – Ready to Integrate Into Your Workflow Accurate detection of Cyclin D1…

Read full article

Milestone – UltraCENTER

Enhance the Efficiency of your Biopsy Workflow UltraCENTER is an advanced workstation designed for the precise handling of fixed biopsy specimens. It focuses on user…

Read full article