Cell Marque Tyrosine Hydroxylase (LNC1) Mouse Monoclonal Antibody

Tyrosine Hydroxylase (TYH) is the rate-limiting enzyme of catecholamine biosynthesiss.^1,2 TYH uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-DOPA, a precursor to dopamine. Anti-TYH is sensitive and specific for peripheral neuroblastic tumors in the differential diagnosis from other tumors of childhood and shows high diagnostic utility. Anti-TYH has been shown to positively label all pheochromocytomas and sympathetic paragangliomas, and thus aids in differentiating them from their histologic mimics such as adrenocortical neoplasms.^3,4

References

1. Daubner, S Colette et al. “Tyrosine hydroxylase and regulation of dopamine synthesis.” Archives of biochemistry and biophysics vol. 508,1 (2011): 1-12. doi:10.1016/j.abb.2010.12.017
2. Loizou, L A. “Effect of inhibition of catecholamine synthesis on central catecholamine-containing neurones in the developing albino rat.” British journal of pharmacology vol. 41,1 (1971): 41-8. doi:10.1111/j.1476-5381.1971.tb09933.x
3. Takemoto, Junkichi et al. “HuC/D expression in small round cell tumors and neuroendocrine tumors: a useful tool for distinguishing neuroblastoma from childhood small round cell tumors.” Human pathology vol. 85 (2019): 162-167. doi:10.1016/j.humpath.2018.11.004
4. Warren, Mikako et al. “Utility of Phox2b immunohistochemical stain in neural crest tumours and non-neural crest tumours in paediatric patients.” Histopathology vol. 72,4 (2018): 685-696. doi:10.1111/his.13412

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