Cytokine Storm Biomarker Quantitation for COVID-19 Research Applications

Last updated: 25th May, 2020

Products are for professional/laboratory use only.  In response to SARS-CoV-2 viral infection of the lungs, a cytokine storm can result. Over-produced immune cells and their signaling molecules cause a local inflammatory response in the lungs leading to respiratory distress and reduced blood oxygen levels. A cytokine storm can contribute to severe clinical symptoms and poor patient outcomes.

Some early publications on the cytokine profile for COVID-19 have found increased levels of IL- 2, IL-7, G-CSF, IP-10, MCP-1, MIP-1α, TNFα, and Ferritin.1 In a separate study, IL-6 was also found to increase with SARS-CoV-2 infection.2

IL-1β, IL- 1RA, IL-8, IL-9, IL-10, FGF-basic, GM-CSF, IFNγ, MIP-1β, PDGF, and VEGF have also been shown to be increased in COVID-19 patients compared to healthy subjects.3

MILLIPLEX® multiplex immunoassays offer researchers the ability to simultaneously quantitate a large number of analytes critical to understanding the immune response in humans. The 48-plex Human Cytokine/Chemokine/Growth Factor Panel A saves time and sample volume for a snapshot of analyte profiles during a cytokine storm, sepsis, or other disease states.


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References

  1. Mehta, P., et al. 2020. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet Published Online March 12, 2020 https://doi.org/10.1016/S0140-6736(20)30630-9
  2. Ruan, Q., et al. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive Care Med (2020). https://doi.org/10.1007/s00134-020- 05991-x
  3. Huang, C., et al. 2020. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Published Online January 24, 2020 https://doi.org/10.1016/S0140-6736(20)30183-5

 


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