New from ZytoVision: BCOR break apart probe

Last updated: 12th January, 2022

Products are for professional/laboratory use only.

Abacus dx is pleased to announce the release of the latest FISH probe from ZytoVision: ZytoLight® SPEC BCOR Dual Color Break Apart Probe*

The ZytoLight® SPEC BCOR Dual Color Break Apart Probe is designed to detect rearrangements involving the chromosomal region Xp11.4 harboring the BCOR gene.

In the 2020 WHO classification of soft tissue and bone tumors, BCOR-rearranged sarcoma is recognised as a distinct entity due to particular morphological, immunohistochemical and molecular features and differing clinical outcomes compared to other undifferentiated sarcomas.

There are considerable overlapping morphological and immunohistochemical features with classical Ewing sarcoma, other subtypes of small round cell tumors, as well as lymphomas and carcinomas. Therefore, the evaluation of the BCOR rearrangement status by FISH may be of diagnostic relevance.


Probe Description

The SPEC BCOR Dual Color Break Apart Probe is a mixture of two direct labelled probes hybridising to the Xp11.4 band. The orange fluorochrome direct labelled probe hybridises proximal, the green fluorochrom direct labelled probe hydridises distal to the BCOR gene.


Sarcoma Probe Brochure

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*Research use only in Australia

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